From Latin antagonista, from Ancient Greek ἀνταγωνιστής (antagōnistḗs, “opponent”) (ἀντί (antí, “against”) + ἀγωνιστής (agōnistḗs, “a combatant, pleader, actor”)), from ἀνταγωνίζεσθαι (antagōnízesthai, “antagonize”).
antagonist (plural antagonists)
- An opponent or enemy.
- One who antagonizes or stirs.
- (biochemistry) A chemical that binds to a receptor but does not produce a physiological response, blocking the action of agonist chemicals.
- (authorship) The main character or force opposing the protagonist in a literary work or drama.
- (anatomy) A muscle that acts in opposition to another.